Next Gen Biz has compiled a list of the top 100 games released in 2006 in North America (in terms of sales). They broke it down in month, genre, etc., but I think most people here are just interested in overall sales (if somebody who deals with this stuff, like Tom, wants the full info I can provide the link). They are presented:
*Name of the game
*Platforms the game was released on
*Copies sold in 2006 in North America (approximate)/Revenue earned in 2006 in North America
*Month released/Publisher
100)Okami
PS2
200K/$8 million
September/Capcom
99)Rayman Raving Rabids
Wii
200L/$10 million
November/Ubisoft
98)Prey
Xbox 360/PC
200K/$11 million
July/Take-Two Interactive
97)F.E.A.R.
Xbox 360 (PC version released in 2005, so not counted)
200K/$12 million
November/Vivendi Games
96)Red Steel
Wii
220K/$11 million
November/Ubisoft
95)Battliefield 2142
PC
220K/$12 million
October/Electronic Arts
94)Tourist Trophy: The Real Riding Simulator
PS2
230K/$9 million
April/Sony
93)Star Fox Command
DS
240K/$8 million
September/Nintendo
92)Daxter
PSP
240K/$10 million
March/Sony
91)Blazing Angels: Squadrons of WWII
Xbox 360/Xbox/PS3/PC
240K/$15 million
March (360 verison, others afterwards)/Ubisoft
90)NFL Street 3
PS2/PSP
260K/$9 million
November/Electronic Arts
89)Family Guy
Xbox/PS2/PSP
270K/$8 million
October/Take-Two Interactive
88)Top Spin 2
Xbox 360/DS/PC/GBA
270K/$9 million
March/Take-Two Interactive
87)Chromehounds
Xbox 360
270K/$11 million
July/Sega
86)Burnout Revenge
Xbox 360 (Xbox and PS2 version released in 2005, not counted here)
270K/$12 million
March/Electronic Arts
85)Kirby Squeak Squad
DS
280K/$7 million
December/Nintendo
84)NBA Ballers: Phenom
Xbox/PS2
280K/$10 million
April/Midway
83)NASCAR 07
Xbox/PS2/PSP
300K/$11 million
September/Electronic Arts
82)Microsoft Flight Simulator X
PC
300K/$17 million
October/Microsoft
81)Battlefield 2: Modern Combat
Xbox 360 (Xbox and PS2 versions released in 2005, not counted here)
300K/$18 million
April/Electronic Arts
80)Resistance: Fall of Man
PS3
300K/$20 million
November/Sony
79)Catz
GBA/DS
310K/$9 million
December/Ubisoft
78)Hannah Montanta
DS
320K/$9 million
October/Buena Vista Games
77)Tetris DS
DS
320K/$10 million
March/Nintendo
76)NFL Head Coach
PS2/Xbox
330K/$11 million
June/Electronic Arts
75)Final Fantasy III
DS
330K/$13 million
November/Square Enix
74)Arena Football
PS2/Xbox
340K/$8 million
February/Electronic Arts
73)FIFA Street 2
PS2/Xbox/GameCube/PSP/DS
340K/$9 million
March/Electronic Arts
72)SOCOM:U.S. Navy SEALs Combined Assault
PS2
340K/$13 million
November/Sony
71)Destroy All Humans! 2
PS2/Xbox
340K/$13 million
October/THQ
70)Naruto: Ultimate Ninja
PS2
350K/$12 million
June/Namco Bandai
69)Naruto: Clash of Ninja
GameCube
360K/$13 million
March/D3 Publisher
68)Dirge of Cerberus: Final Fantasy VII
PS2
360K/$18 million
August/Square Enix
67)Superman Returns: The Video Game
PS2/Xbox/Xbox 360/GBA/DS
370K/$5 million
November/Electronic Arts
66)Jaws Unleashed
PS2/Xbox
370K/$10 million
May/Majesco
65)Mario vs. Donkey Kong 2: March of the Minis
DS
370K/$11 million
September/Nintendo
64)Super Princess Peach
DS
380K/$13 million
February/Nintendo
63)Eragon
PS2/Xbox/Xbox 360/PC/PSP/DS/GBA
400K/$16 million
November/Vivendi Games
62)Metroid Prime Hunters
DS
410K/$14 million
March/Nintendo
61)Mario Hoops: 3 on 3
DS
420K/$13 million
September/Nintendo
60)Star Wars: Empire at War
PC
420K/$18 million
February/LucasArts
59)Bully
PS2
440K/$18 million
October/Take-Two Interactive
58)Rampage: Total Destruction
PS2/GameCube/Wii
460K/$10 million
April (Wii in November)/Midway
57)Bratz: Forever Diamondz
DS/GBA/PS2
460K/$13 million
September/THQ
56)The Legend of Spyro: A New Beginning
PS2/GameCube/Xbox/DS/GBA
460K/$16 million
October/Vivendi Games
55)Dragon Ball Z: Budokai Tenkaichi 2
PS2/Wii
460K/$20 million
November/Atari
54)SpongeBob SquarePants: Creature from the Krusty Krab
PS2/DS/Wii/GBA/GameCube
470K/$16 million
October (November for Wii)/THQ
53)Thrillville
PS2/Xbox/PSP
470K/$18 million
November/LucasArts
52)Tom Clancy's Rainbow Six: Vegas
Xbox 360/PC
480K/$28 million
November/Ubisoft
51)Happy Feet
PS2/Wii/GameCube/PC/DS/GBA
500K/$16 million
November/Midway
50)Dance Dance Revolution: Super Nova
PS2
500K/$28 million
September/Konami
49)Pirates of the Caribbean: Dead Man's Chest
GBA/DS/PSP
550K/$15 million
June/Vivendi Games
48)Yoshi's Island DS
DS
550K/$17 million
November/Nintendo
47)X-Men: The Official Game
PS2/Xbox/Xbox 360/GameCube/PC/DS
550K/$20 million
May/Activision
46)Mortal Kombat: Armageddon
PS2/Xbox
550K/$23 million
October/Midway
45)The Lord of the Rings: Battle for middle-Earth II
PC/Xbox 360
550K/$28 million
March/Electronic Arts
44)The Sims 2: Pets
DS/PS2/GameCube/PSP/GBA
580K/$20 million
October/Electronic Arts
43)Nintendogs: Dalmation & Friends
DS
600K/$18 million
October/Nintendo
42)Tomb Raider: Legend
Xbox 360/Xbox/PC/PS2/PSP/GameCube/GBA/DS
600K/$28 million
April (August for GameCube)/Eidos Interactive
41)Dead Rising
Xbox 360
600K/$35 million
August/Capcom
40)Saints Row
Xbox 360
610K/$36 million
August/THQ
39)Ice Age 2: The Meltdown
PS2/PC/Xbox/GameCube/Wii/GBA/DS
630K/$22 million
March (December for Wii)/Vivendi Games
38)Hitman: Blood Money
Xbox 360/Xbox/PS2/PC
650K/$30 million
May/Eidos Interactive
37)MVP 06 NCAA Baseball
PS2/Xbox
700K/$20 million
January/Electronic Arts
36)NBA 2K7
Xbox 360/Xbox/PS3/PS2
700K/$30 million
September (November for PS3)/Take-Two Interactive
35)Tom Clancy's Splinter Cell: Double Agent
Xbox 360/Xbox/PC/PS2/GameCube/Wii
700K/$37 million
October (November for Wii)/Ubisoft
34)Avatar: The Last Airbender
PS2/Wii/GameCube/PSP/Xbox/PC/GBA/DS
720K/$30 million
October (November for Wii)/THQ
33)Big Brain Academy
DS
750K/$16 million
June/Nintendo
32)Sonic Riders
GameCube/PS2/Xbox
780K/$26 million
February/Sega
31)FIFA Soccer 07
PS2/Xbox/Xbox 360/GameCube/PC/PSP/GBA/DS
800K/$34 million
October/Electronic Arts
30)Tiger Woods PGA Tour 07
PS2/PS3/Xbox/Xbox 360/PC/PSP
800K/$37 million
October (November for PS3)/Electronic Arts
29)The Godfather: The Game
PS2/Xbox/Xbox 360/PC
880K/$40 million
March (September for Xbox 36)/Electronic Arts
28)Tony Hawk's Project 8
PS2/PS3/Xbox/Xbox 360/PSP
900K/$44 million
November/Activision
27)Over the Hedge
PS2/PC/DS/GameCube/Xbox/GBA
910K/$30 million
May/Activision
26)MLB 06: The Show
PS2/PSP
910K/$35 million
March/Sony
25)Black
PS2/Xbox
950K/$30 million
March/Electronic Arts
24)2006 FIFA World Cup
PS2/PSP/Xbox/Xbox 360/GameCube/PC/GBA/DS
950K/$33 million
April/Electronic Arts
23)Major League Baseball 2K6
Xbox 360/Xbox/GameCube/PS2/PSP
950K/$40 million
April/Take-Two Interactive
22)Scarface: The World is Yours
PS2/Xbox/PC
970K/$47 million
October/Vivendi Games
21)Grand Theft Auto Liberty City Stories
PS2 (PSP version released in 2005, not counted here)
1 million/$20 million
June/Take-Two Interactive
20)Marvel: Ultimate Alliance
PS2/PS3/PSP/Xbox/Xbox 360/Wii/PC/GBA
1 million/$50 million
October (November for PS3 and Wii)/Activision
19)Brain Age: Train Your Brain in Minutes a Day!
DS
1.1 million/$22 million
April/Nintendo
18)NBA Live 07
PS2/PSP/Xbox/Xbox 360/PC
1.2 million/$50 million
September/Electronic Arts
17)WWE SmackDown vs. RAW 2007
PS2/PSP/Xbox 360
1.2 million/$60 million
November/THQ
16)Final Fantasy XII
PS2
1.2 million/$65 million
November/Square Enix
15)Pokemon Mystery Dungeon: Blue Rescue Team/Pokemon Mystery Dungeon: Red Rescue Team
DS (Blue)/GBA (Red) {note: I HATE when they combine Pokemon games for sales}
1.3 million/$45 million
September/Nintendo
14)Guitar Hero II
PS2
1.3 million/$95 million
November/Activision
13)Tom Clancy's Ghost Recon: Advanced Warfighter
Xbox 360/Xbox/PS2/PSP/PC
1.4 million/$75 million
March (May for PC)/Ubisoft
12)The Elder Scrolls IV: Oblivion
Xbox 360/PC
1.4 million/$80 million
March/Take-Two Interactive
11)The Legend of Zelda: Twilight Princess
Wii/GameCube
1.5 million/$75 million
November (December for GameCube)/Nintendo
10)Need for Speed: Carbon
PS2/PS3/PSP/Xbox/Xbox 360/PC/GameCube/Wii/GBA/DS
1.6 million/$74 million
November/Electronic Arts
9)Fight Night Round 3
Xbox 360/Xbox/PS2/PSP/PS3
1.6 million/$80 million
February (December for PS3)/Electronic Arts
8)Call of Duty 3
Xbox 360/Xbox/Wii/PS2/PS3
1.7 million/$90 million
November/Activision
7)Kingdom Hearts II
PS2
1.7 million/$90 million
March/Square Enix
6)Gears of War
Xbox 360
1.8 million/$110 million
November/Microsoft
5)New Super Mario Bros.
DS
2 million/$70 million
May/Nintendo
4)NCAA Football 07
PS2/Xbox 360/Xbox/PSP
2.2 million/$100 million
July/Electronic Arts
3)LEGO Star Wars II: The Original Trilogy
PS2/PC/PSP/Xbox/Xbox 360/GameCube/GBA/DS
2.5 million/$95 million
September/LucasArts
2)Cars
PS2/PSP/GameCube/Wii/Xbox/Xbox 360/GBA/DS
2.6 million/$85 million
June (November for Wii)/THQ
1)Madden NFL 07
PS2/PS3/PSP/PC/Xbox/Xbox 360/GameCube/Wii/GBA/DS
6.5 million/$300 million
August (November for PS3 and Wii)/Electronic Arts