Manchester United striker Wayne Rooney will spearhead their attack as they begin the defence of their title.
He has recovered from a virus, but Nani is suspended and Cristiano Ronaldo injured, so Michael Carrick may start.
Newcastle have included new Argentine defender Fabricio Coloccini, but Joey Barton has not been considered.
Skipper Michael Owen, Mark Viduka and Andy Carroll are all injured and Shola Ameobi is talking to Ipswich, but Obafemi Martins is set to feature. <!-- E SF -->
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Man Utd (from): Van der Sar, Kuszczak, Neville, Brown, R Da Silva, Ferdinand, Vidic, O'Shea, Evans, Evra, Silvestre, F Da Silva, Carrick, Scholes, Fletcher, Gibson, Possebon, Giggs, Martin, Tevez, Rooney, Campbell.
Newcastle (from): Given, Beye, N'Zogbia, Taylor, Coloccini, Enrique, Cacapa, Bassong, Edgar, Butt, Geremi, Milner, Duff, Guthrie, Gutierrez, Martins, Smith, Edgar, Harper.
Manchester United begin the challenge for a record 11th Premier League title. A second hat-trick of such titles would see Sir Alex Ferguson's Red Devils crowned champions of England for the 18th time, and put them on a par with Liverpool's 18-year-old record.
Newcastle last won the league championship in 1927, and have not claimed a major piece of silverware for 39 years, since the European Fairs Cup in 1969.
Manchester United ran riot against Newcastle last season. Cristiano Ronaldo scored his first hat-trick for the club as they won this corresponding fixture 6-0, three days after the Magpies had parted company with Sam Allardyce, and four days before the arrival of Kevin Keegan.
The Red Devils went on to complete the 'double' over the Magpies with an 11-1 aggregate.
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