West Ham defender Anton Ferdinand is a doubt with a hamstring problem.
Craig Bellamy, Kieron Dyer, Jonathan Spector, James Collins, George McCartney, Danny Gabbidon and James Tompkins are already out injured.
Chris Kirkland (back) and Emile Heskey (groin) have both been passed fit to play for Wigan, while Jason Koumas (knee) is also expected to be fit.
But Paul Scharner (ankle) and Ryan Taylor (shin) are unavailable and Erik Edman (knee) is a long-term absentee. <!-- E SF -->
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West Ham (from): Green, Stech, Neill, Ferdinand, Davenport, Etherington, Reid, Faubert, Parker, Noble, Behrami, Boa Morte, Ashton, Mullins, Cole, Sears, Collison, Hines.
Wigan (from): Kirkland, Nash, Pollitt; Boyce, Bramble, Figueroa, Melchiot, Montrose, Scharner; Brown, Cattermole, De Ridder, Kapo, Kilbane, Koumas, Palacios, Taylor, Valencia; Camara, Heskey, Sibierski, Zaki.
West Ham are setting off on their fourth consecutive Premier League campaign since their return to the big time in 2005.
Wigan, the most junior club in the Premier League, are mixing it once again with the elite for the fourth season in a row since their arrival in 2005.
Alan Curbishley is sending out a Hammers side for the 60th time in this league; Steve Bruce is starting his first full season as manager of the Latics, with his 25th Premier League game in charge.
Wigan have not lost at Upton Park since their very first league match there, when they were hammered 4-0 at second league level on 29 November 2003.
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