Everton have Steven Pienaar, Tim Cahill, Tony Hibbert, James Vaughan and Andy van der Mayde out injured and Victor Anichebe at the Olympics.
Jack Rodwell, Dan Gosling, Jose Baxter and Lukas Jutkiewicz may all feature.
Blackburn's Brett Emerton will be included in new manager Paul Ince's squad despite a bruised foot.
Striker Roque Santa Cruz (Achilles) should also feature but new signing Carlos Villanueva is still recovering from a bout of chicken pox. <!-- E SF -->
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Everton (from): Howard, Ruddy, Turner, Neville, Jagielka, Lescott, Yobo, Valente, Baines, Osman, Arteta, Rodwell, Gosling, Baxter, Yakubu, Jutkiewicz, Agard, Kissock, Wallace.
Blackburn (from): Robinson, Ooijer, Warnock, Samba, Tugay, Nelsen, Emerton, Dunn, Santa Cruz, McCarthy, Pedersen, Khizanishvili, Vogel, Mokoena, Reid, Gallagher, Peter, Derbyshire, Roberts, Simpson, Brown.
Everton and Blackburn are two founder members of the Football League, embarking on their 110th campaigns.
Paul Ince succeeded Mark Hughes in the Blackburn hot seat on 23 June, and is one of five Premier League managerial debutants, and one of three in the top league to start life with a new club this season.
This will be the first of 42 north-west derbies in the Premier League this season.
Blackburn are making the shortest journey of any of the Premier League clubs this weekend.
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