Arsenal winger Samir Nasri is set to make his Gunners debut after recovering from thigh and knee complaints.
Kolo Toure will also be in the squad, but Cesc Fabregas, Abou Diaby, Philippe Senderos, Amaury Bischoff , Tomas Rosicky and striker Eduardo are out.
Abdoulaye Meite will make his debut for West Brom in place of Neil Clement (knee) after his arrival from Bolton.
The Baggies are also without Luke Moore (thigh), Robert Koren (knee ligaments) and Gianni Zuiverloon (Olympic duty).
Arsenal (from): Almunia, Sagna, Toure, Gallas, Clichy, Nasri, Ramsey, Denilson, Walcott, Adebayor, Van Persie, Fabianski, Eboue, Djourou, Bendtner, Vela, Wilshere, Gibbs.
West Brom (from): Carson, Kiely, Hoefkens, Barnett, Meite, Cech, Morrison, Greening, Kim, Brunt, Bednar, Miller, Pele, Beattie, MacDonald, Dorrans, Hodgkiss.
Arsenal begin the quest for a fourth Premier League title, from their 83rd consecutive season of top flight football.
West Bromwich Albion, under Tony Mowbray, return to the big league after an absence of two seasons. Of the 16 sides promoted as champions of the second tier, only 10 have avoided immediate relegation.
Arsene Wenger's side, who've already notched a handy 2-0 lead away to FC Twente in the Champions League qualifier, have not lost a Premier League opening day fixture for eight years; the Baggies have never won one.
West Brom travel in search of their first win at Arsenal in a quarter of a century.