April 17 (Bloomberg) -- Giving marijuana to mice with cancer shrank their lung tumors by half and slowed spread of the disease, findings that may one day expand legal use of the substance as a treatment, researchers said.
The research is the first to show that marijuana's active ingredient, tetrahydrocannabinol, or THC, blocks a known cancer- related protein that's already the target of drugs such as ImClone System Inc.'s Erbitux and Amgen Inc.'s Vectibix.
The findings, presented today at the American Association for Cancer Research meeting in Los Angeles, add to evidence that marijuana may have anti-tumor properties and its potential should be probed further, researchers said. Scientists speculate THC may activate biological pathways that halt cancer cell division or block development of blood vessels that feed tumors.
``THC can have a potential therapeutic role,'' said Anju Preet, the study's lead author and a researcher at Harvard University's division of experimental medicine. ``Maybe THC is killing cells. The preliminary studies are promising.''
Tumor cells dosed with THC also showed a reduction in epidermal growth factor receptor, or EGFR, which means the substance may be acting in ways similar to Erbitux and Vectibix, which block the protein, Preet said.
The group includes Erbitux, which treats colon and head and neck cancers, Vectibix, which treats colon cancer, Genentech Inc.'s Tarceva, approved for lung and pancreatic cancer, and AstraZeneca Plc's Iressa, which treats lung cancer.
Lung cancer cells with high levels of EGFR are generally very aggressive and treatment resistant, researchers said.
Receptors
THC activates ``cannabinoid receptors,'' which are proteins found in the brain and other parts of the body that are involved in a number of biological functions, including inflammation and pain. Researchers set out to see if they could inhibit tumor growth by targeting these receptors in both human lung tumor samples and in mice.
In addition to reducing tumor size by half, THC was also associated with a 60 percent reduction in cancer lesions in the lungs of mice.
A British study of nine brain-tumor patients last year found THC reduced growth of cancer cells, and other tests suggest it has potential in skin and breast cancers, Preet said.
More work needs to be done to understand how THC prevents tumor growth and to find the right dose before starting clinical trials, Preet said. Previous research has shown that too much THC can stimulate cancer growth, she said.
``Before jumping into clinical study we need to understand how it works, which can help us design a better therapeutic,'' Preet said.
In the U.S., 11 states have enacted laws that allow patients to use marijuana for medical purposes. The states are Alaska, California, Colorado, Maine, Montana, Nevada, Oregon, Washington, Hawaii, Vermont and Rhode Island, according to the Marijuana Policy Project, a marijuana policy reform organization based in Washington D.C. Last month, Bill Richardson, the governor of New Mexico, signed a bill that would make his state the 12th to legalize marijuana for medical use.
Only one THC drug, called Marinol, is approved in the U.S. The treatment, made by Solvay Pharmaceuticals, is used as an appetite stimulant for cancer patients.
Man, there are too many useful things for weed for it to still be illegal. Its almost ridiculous at this point. It also reeks of hypocrisy when its a plant that grows out of the ground as is. Nothing added when compared to alchohol or even cigarettes.
Heavy Machinery my ass.
It's about time......now bring on his next fued....
Re: Marijuana Stops Growth of Lung Cancer Tumors in Mice,but still gave them The Munc
Well, this is good news medically, but it is a tough arguement to make maijuana legal for all. Morphene helps many who are in immense pain, but not everyone can take it legally. If marijuana helps some patients, then it should be prescribed to them for a medical treatment. To legalize it is a different story.
I support it, I suppose. If people want to smoke up, then they should go ahead. The government could make a ton of money off it. I just hope they keep it the same as cigarette laws (in Canada at least), and make sure people have to do it outdoors. I am allergic to marijuana and cigarette smoke, my throat swells up, gets infected, and I can't breathe, then I have to spend the night in the hospital on IV. I really don't like it. Keep them outside, don't allow them to drive (it should be handled the same way as driving under the influence of alcohol), and I am all for the happy stoners.
Re: Marijuana Stops Growth of Lung Cancer Tumors in Mice,but still gave them The Munc
Quote:
Originally Posted by Erin
Well, this is good news medically, but it is a tough arguement to make maijuana legal for all. Morphene helps many who are in immense pain, but not everyone can take it legally. f marijuana helps some patients, then it should be prescribed to them for a medical treatment. To legalize it is a different story.
I support it, I suppose. If people want to smoke up, then they should go ahead. The government could make a ton of money off it. I just hope they keep it the same as cigarette laws (in Canada at least), and make sure people have to do it outdoors. I am allergic to marijuana and cigarette smoke, my throat swells up, gets infected, and I can't breathe, then I have to spend the night in the hospital on IV. I really don't like it. Keep them outside, don't allow them to drive (it should be handled the same way as driving under the influence of alcohol), and I am all for the happy stoners.
Re: Marijuana Stops Growth of Lung Cancer Tumors in Mice,but still gave them The Munc
Quote:
Originally Posted by Erin
Well, this is good news medically, but it is a tough arguement to make maijuana legal for all. Morphene helps many who are in immense pain, but not everyone can take it legally. If marijuana helps some patients, then it should be prescribed to them for a medical treatment. To legalize it is a different story.
I support it, I suppose. If people want to smoke up, then they should go ahead. The government could make a ton of money off it. I just hope they keep it the same as cigarette laws (in Canada at least), and make sure people have to do it outdoors. I am allergic to marijuana and cigarette smoke, my throat swells up, gets infected, and I can't breathe, then I have to spend the night in the hospital on IV. I really don't like it. Keep them outside, don't allow them to drive (it should be handled the same way as driving under the influence of alcohol), and I am all for the happy stoners.
I completely agree with this statement.
As long as it is treated as alcohol in relation to driving under the influence I have no problem with it being legalized.
The destruction of the past is perhaps the greatest of all crimes.
- Simone Weil
Re: Marijuana Stops Growth of Lung Cancer Tumors in Mice,but still gave them The Munc
Driving isn't that hard when you're high...but it makes hills look like giant pussy's...but I usually drive uber slow so I'm not too worried...but w00t weed.
Re: Marijuana Stops Growth of Lung Cancer Tumors in Mice,but still gave them The Munc
I've gotten stoked a couple times in the last month. I'm all for the legalization. Tax it like cigaretts and shit, and treat it like alcohol when driving and what not. The government could make multi-MILLIONS at the very least, from taxing it and everything. Nobody ever smokes themselves to death, or is so high they crash and kill someone. It's really unheard of. It's always they harder drugs and alcohol that causes the problems.
Re: Marijuana Stops Growth of Lung Cancer Tumors in Mice,but still gave them The Munc
Quote:
Originally Posted by Suffy
Driving isn't that hard when you're high...but it makes hills look like giant pussy's...but I usually drive uber slow so I'm not too worried...but w00t weed.
We have got to get together and toke up one of these days.